ABSTRACT

LipL21 is a novel surface exposed lipoprotein which is expressed during infection and conserved among pathogenic species of Leptospira. Lipoproteins have been shown to play a key role in adhesion to host cells, modulation of inflammatory processes and translocation of virulence factors into the host cells. In this study, bioinformatics approach has been adopted to explore the properties of LipL21. Protein modeling of LipL21was performed to understand the insights of the molecular structure. The species of Leptospira was clustered together and form a group with highest bootstrap value. B-cell epitopes prediction of LipL21 found to be potential, so this study might be useful in creating the peptide vaccines that target the lipoprotein surface epitopes expressed during Leptospira. Keywords: Leptospira, LipL21, hydropathicity, protein modelling, epitope, bioinformatics
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_5934.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.5934