ABSTRACT

Reliable experimental animal models of human diseases are critically important for the discovery of molecular pathways, genetic influences, environmental factors, and successful management strategies for humans. Inflammation is an immune response to stimuli. It begins with activation of the innate immune system by infectious or noninfectious (sterile) stimuli, and inflammasomes act as sensors and effectors of these stimuli. We need to understand recent findings on the cause of inflammation, immune system responses, and possible results when prostate is inflamed. Animals experimentally affected by such diseases provide a unique opportunity to uncover disease associated pathways, which are complicated or even impossible to define in man. Prostatitis is an important worldwide health problem in men. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This Paper theoretically explored a number of experimental rodent models of prostatitis. Keywords: Disease associated pathways, Immune system, Inflammasomes, Poly- and mononuclear cell infiltrates multifactorial etiology, Prostatitis models
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_5905.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.5905