ABSTRACT

Fundamental bases of androgen deprivation in the aging male remain unknown despite their recognition biochemically almost 6 decades ago. Epidemiologically the testosterone (Te) deficiency has been associated with impaired quality of life. The main objective of the study is to evaluate the levels MDA, GSH, SOD, total testosterone, SHBG, FSH and LH in healthy aging males from Punjab-Pakistan. The individuals were divided into two groups, Group I from less than 40 years and Group II from more than 40 years. The levels of MDA, GSH and SOD were determined according to their respective protocols, while the levels of TT, FSH, LH and SHBG were measured by human diagnostic ELISA kit methods. The hematological profile was determined by automated analyzer method. The mean values of GSH (0.17±0.005 ?mol/L vs. 3.56±0.56 ?mol/L) and SOD (0.17±0.005 U/gHb vs. 0.11±0.002 U/gHb) were significantly increase in healthy males with group I (less than ?40) as compared to group II (more than ?40) respectively. On the other hand, the high level of MDA was observed in healthy male with age group II (4.15±1.26 nmol/ml) as compared to group I (3.015±0.23 nmol/ml). The mean values of SHBG (40.5±4.25 nmol/l vs. 29.0±6.26 nmol/l), LH (26.25±6.65 mIU/ml vs. 3.9±3.26 mIU/ml) and FSH (76.92±8.15 mIU/ml vs. 2.28±4.56 mIU/ml) were significantly increase in healthy group with age group II (more than ?40) as compared to group I (less than ?40). While, the increased levels of total testosterone was recorded in-group I (500.12±25.58 ng/dl) as compared to group II (7.14±1.44 ng/dl) of healthy males from Punjab-Pakistan. This study indicated a significant descent in the levels of testosterone with an advancing age. It is further supported by the evidence that the failure in the hypothalamic-pituitary unit in response to decreasing levels of testosterone is the primary defect of advancing age. Key words: MDA, GSH, SOD, FSH, LH, SHBG
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5978.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5978