ABSTRACT

In males, there are alterations at all levels of the hypothalamic-pituitary-gonadal axis as a result of aging, including changes in GnRH pulse generator, the release of gonadotropins by anterior pituitary and steroidogenesis by the testis. There is a decrease in circulating testosterone levels with advancing age as a result of changes in feed-forward and feedback mechanisms involved in hormone synthesis of the HPG axis. The objective of the research is to study age-related trajectories of TT, FT, BAT, FSH, LH, SHBG in aging males of Central Punjab.A total of 98 subjects were selected aged 18 to 103 years. Subjects were divided into four age groups. Group I from 18 to 37.9 years, group II from 38 to 57.9 years group III from 58 to77.9 years, group IV is 78years onwards. Subjects with acute or chronic illness affecting the hypothalamic-pituitarygonadal axis or taking any medication were excluded. Samples were drawn from the cubital vein. The serum was separated by centrifugation within two hours of sample collection.TT, SHBG, LH, FSH in the serum were analyzed.Collected data were entered and analyzed using IBM-SPSS (statistical package for social sciences), version 20. One way ANOVA test was used to compare variables between four groups.There was a highly significant difference between FT and BAT between the four groups with a p-value of 0.000. The results for SHBG, LH, FSH are also significant with p-value < 0.005. These results strongly support the hypothesis that there is a progressive decrease in serum-free testosterone and bioavailable testosterone level with aging and progressive increase in SHBG, LH, and FSH. The TT shows a declining trend with advancing age.It is clear from the study that male reproductive hormones decline with an increasing age. Keywords: FSH, LH, SHBG, Aging
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5977.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5977