ABSTRACT

Delivering the drugs by oral route is considered to be one of the most favored route of drug administration. People often consume oral solids, especially OTC drugs, at any time before or after breakfast with water or any other available hot or cold beverages. Crocin is one of the popular OTC brands of paracetamol, which is preferred in large number. Patient consumes this OTC tablet any time before or after meal or breakfast. However, breakfast interact with paracetamol, affecting the release of drug. Taking this into consideration, current study was planned to assess the effect of some most common Indian breakfasts on release of paracetamol (crocin tablet) tablet using USP type II dissolution apparatus. Dissolution media used was modified phosphate buffer (with pH 5.8), which was further added with breakfast and was analyzed by UV spectrophotometrically. Dissolution profile revealed the maximum drug release 97.03 ± 1.29 % in plain water was while minimum with dosa 28.87 ± 2.00 %. In conclusion, Paracetamol should be taken with water and should be taken after sufficient time interval of breakfast. Keywords: Breakfast, crocin, paracetamol, tablet, dissolution
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5968.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5968