ABSTRACT

This study explores hepatoprotective and nephroprotective activities of herbal formulation of alcoholic extracts of Abies webbiana against experimental induced hepatotoxicity and nephrotoxicity by carbon tetra chloride and cisplatin respectively. Development of herbal suspension ware done simple procedure by using a suspending agent with water. The developed formulations were evaluated for organolepetic and physicochemical properties. Stability studies ware carried out formulation taking gallic acid as the marker compound for 90 days at two temperature; 300C and 65% RH and 400C and 75% RH. Effects of suitable formulation were checked acute toxicity and on liver and kidney biomarkers. Formulation (FM-2) is better than FM-1 and FM-3 on the basis of their physicochemical parameters and their stability studies. Acute toxicity was performed and its biological activities of formulation (FM-2) at two doses 5 ml/kg and 10 ml/kg (p. o.) were evaluated hepatotoxicity and nephrotoxicity studies. It was found that liver and kidney biomarkers reduced by formulation, which were increased by CCl4 and cisplatin respectively. Formulation is demonstrated the dose-dependent hepatic and nephro protective roles. Keywords: Abies webbiana, Herbal formulation, Hepatoprotective, Nephroprotective
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5963.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5963