ABSTRACT

Anti epileptics are used in the adequate and impressive control and management of CNS disorders essentially characterized by recurrent attacks of disturbed brain function which ultimately give rise to motor, sensory, and psychic sequence of events. Divalproex Sodium (DS) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy of bipolar disorder and depression. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. On literature survey, it was found that not much work has been done on this particular drug for its determination in bulk and pharmaceutical dosage forms using chromatographic techniques.This review covers most recent analytical methods such as various chromatographic methods and other methods for determination of Divalproex Sodium in various pharmaceutical dosage forms were reported. Keywords: Divalproex Sodium; Analytical Methods; Anti epileptic drug
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5956.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5956