ABSTRACT

Asthma is a chronic pulmonary disease that affects both children and adults in both developed and developing countries. It is becoming more common and serious, particularly among allergic patients. Herbs have been paid more attention since they have very little side effects. Tylophora indica (Asclepiadaceae) was used in traditional medicine for the treatment of asthma. The primary goal of this study is to develop a novel herbal spray using Tylophora indica. To achieve this goal, various techniques such as extraction, spray drying, preformulation studies such as solubility of herbal extracts, and Fourier transmission infrared spectroscopy (FT-IR) studies for herbal extract were investigated. Their quality control, stability, and efficacy studies were carried out in accordance with the guidelines of the United States Pharmacopoeia (USP) and the International Conference on Harmonization (ICH). Histamine-induced bronchial hyper reactivity in Guinea pigs was used to assess antiasthmatic activity. The quality control test results were in accordance with USP standards. The particle size of the normal formulation (13.9µ) was approximately 4–5 times that of the spray-dried formulation (2.9µ). When the spray-dried test formulation was tested using the histamine-induced bronchial hyper reactivity method, a significant p value was found. The percent protection of PCD (pre convulsion dysponea) in seconds was measured after 1hour, 3hours, and 24hours of administration of histamine aerosol for the test group. The current study attempted to design and develop a novel drug delivery system using herbal medicine to treat Asthma. An FT-IR compatibility study for the herbal formulation was performed, as well as behavioral studies. Keywords: Asthma, Tylophora indica, Spray drying
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5940.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5940