ABSTRACT

The emergence of a novel strain of ß-coronavirus in Wuhan in early December 2019, signaled what were to be the most harrowing months for humanity in recent memory. Studies relating to the epidemiology and pathophysiology of the SARS-CoV-2 virus and its mutant variants, the causative pathogens for the COVID-19 pandemic and its second surge, revealed that the viral coat carried a spike protein specific to the angiotensin-converting enzyme 2 (ACE2)-receptors found on type II pneumocytes in the alveoli of human lungs. Victims of the pathogen primarily demonstrate pneumonia-like symptoms and a fatal cytokine storm, the combination of which leads to acute respiratory distress syndrome (ARDS) and systemic inflammatory response syndrome (SIRS). However, as the disease began to spread globally, a multitude of varied symptoms was brought to the fore, one of the most significant being neurological. With a rise in the prevalence of the long-term effects of the disease (Long COVID), it would be interesting to study the neurological changes which have either arisen or have continued onwards from the spark of initial infection. There are several reports of persistent neurological effects of the disease, ranging from mild symptoms including pain, sleep disorder, and all the way to the rare cases of GuillainBarre syndrome. This review aims to consolidate these severe aftermath related to COVID-19 and Long COVID, with special emphasis on the dilapidating neurological conditions. Keywords: COVID-19, Long COVID, neurological effects, SARS-CoV-2
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5936.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5936