ABSTRACT

The diverse ecosystem of different microbial colonies inhabiting in the human intestine are known as gut microbiota. This gut microbiota regulates our immunity to prevent from pathogens by maintaining the gut barrier permeability. Any change in the symbiotic co-existence of these microbiota ecosystem is termed as ‘dysbiosis’ responsible for various autoimmune disorders. Psoriasis is one of the autoimmune dermatological condition characterised by erythema and epidermal hyperkeratosis which is influenced by dysbiosis. Dysbiosis leads to increased permeability of gut barrier triggering the various immunological cascade events through activation of T lymphocytes. This is the onset point of pathogenesis of psoriasis which later involves various influencing factors like interleukin (IL)-22, IL-17, IL-6, interferons (IFNs), tumor necrotising factors (TNF), etc. The widespread use of immunosuppressive drugs and antibiotics for long term is not satisfactory as per overall health concern of psoriatic patients due significant disrupting effects on gut flora. Thus, recent advanced studies are focusing on the treatment modalities which will strengthen pre-established microbial ecosystem. Ayurveda is a traditional and holistic healthcare system that strongly believe in the managing overall health of diseased person without disrupting existed ecosystem. Virechana (therapeutic purgation) is one of the methods of internal bio purification documented in Ayurveda and it is being practised in India for treating psoriasis for thousands of years. It has been witnessed for its significant clinical efficacy in psoriasis and various autoimmune ailments. Present study emphasizes the attention over virechana for further clinical researches and to explore the complexity of microbial system. Keywords: Gut flora; Dysbiosis; Gut ecosystem; Immunity; Dermatosis; Virechana
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5935.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.3.5935