ABSTRACT

Alzheimer's disease (AD) is a chronic, progressive disease marked by memory loss and cognitive deficits. Various etiological factors are there which are responsible for the development of the Alzheimer’s disease. Oxidative stress is one of the etiological factors which involved in the progression of the AD. It leads to the damage of the nerve fibres and accumulation of the beta amyloid in the nerve cells which further leads to decrease in the level of acetylcholine in the brain. Aggregation of beta amyloid in the nerve cells is the hall marks of AD. Acetylcholinesterase inhibitors, such as tacrine donepezil, galantamine, rivastigmine, and physiostigmine, can help to restore cholinergic activity, which has been linked to memory loss. Phytochemicals can play a major role in the management of AD. As, the most of the phytochemicals possess antioxidant activity and reduce the oxidative stress in the AD. This review focuses on the plant based active phytoconstituents that have been identified to be beneficial in the Alzheimer’s disease during the pre-clinical studies. Keywords: Alzheimer, oxidative stress, phytochemicals, beta-amyloid
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5928.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5928