ABSTRACT

Parkinson disease introduced to the category of neurologic diseases which can cause the motion issues similar to the PD, for example brady-kinesia, resting shaking, rigidity and another is the flexed structure, “freezing,” and lack of the postural reflexrs. PD is the steadily progressing Parkinsonism syndrome which can affect the one part of the body and then spread to other part of the body. In a sub-stantianigra pars Compacta, the pathologic loss of the neuromelanin contained the mono-amine neuron, especially DA neurons in the existence of the cytoplasmic eosinophilic inclusion in the mono-amine neurons is the pathology trademark. A hereditary basis of the unusual Parkinson’s disease types of the Mendelian inheritance, which account for less than the 10 % of the cases have been studied over the last decennium. Do far more than sixteen loci and eleven associated genes have been discovered with the genome wide association studied demonstrating the polymeric variations in these genes play a role in the sporadic Parkinson’s disease. A understanding of the roles of their protein product has shown the neuro-degeneration mechanisms that might be common to both hereditary and the sporadic Parkinson's disease. The key tasks of the next decennium will be to strength these findings and then find another convergence point by discovering the new genes responsible for the Mendelian types of the Parkinson's disease and exploring their roles and relationships. In this study we attempt to summarize the available knowledge on the main genes which are involved in the Parkinson’s disease. Keywords: Parkinson's disease, neuro-degeneration, Parkinsonism syndrome
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5922.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5922