ABSTRACT

About three quarters population around the world is depended upon traditional medicines for treatment of diseases. The medicinal plants are source of natural product having various phytochemicals. Presence of phenolic acids and other root specific compounds in Aqueous Root Extract of Decalepis hamiltonii, major component in herbal drink, Nannari may also inhibit the hOAT1 transporter and may precipitate herb-drug interaction with hOAT1 substrate drugs. Therefore the study is conducted to evaluate the inhibitory effect of aqueous root extract of Decalepis hamiltonii (AREDH) on rat Oat1, a homologous transporter of human OAT1. The present study was conducted on Albino rats by administration of Decalepis hamiltonii aqueous root extract for 28 days and estimation of plasma concentrations of Para Amino Hippuric acid (PAH) after IV bolus administration on 28th day. The results shows significant decrease in CL & k10, and significant elevation in t1/2?, AUC0-? & Vss of PAH in test group compared to control group clearly indicates the cumulative inhibitory effect of phenolic acids present in the AREDH. Further, the co-administration of AREDH with any hOAT1 substrate, results in decrease in clearance and increase in the bioavailability and half-life of the substrate drugs. Therefore, if the elevation in plasma concentrations of hOAT1 substrate drugs is within the therapeutic window, the patient may not experience the adverse effects. But, if the plasma concentrations are above the therapeutic window the patient may experience the adverse effects which are not usually observed at the dose of the substrate drug. Keywords: Medicinal plant, Drug interaction, Albino rats, OAT1 transporters, Pharmaceutical drug
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5834.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.3.5834