ABSTRACT

Carbon dots are the new class of small nanoparticles with a particle size of less than 10nm used for the treatment of various cancers like breast cancer, liver cancer, skin cancer, prostate cancer etc. In recent years, CDS are used for the attachment of several drugs and/or ligands due to its ability to act on the targeting site. Low dimensional (<10nm) quantum dots have received great attention for potential use in biomedical applications (diagnosis and therapy) for which large nanoparticles (>10nm) are not suitable. We explored the biological activity of these CDS in different applications namely bioimaging, biosensors, optronics, apoptosis of cancer cells. The CDS are synthesized by using different techniques and investigated by spectral methods. The cytotoxic effect of CDS on cancer cells compared with a standard drug, showing significant results. These CDS exhibits strong fluorescence with maximum around 670nm. To further understand the role of CDs towards cytotoxicity, confocal or fluorescence microscopy and flow cytometry analysis were carried out. These CDS shows increased cancer therapy efficiency through the localization of much higher concentration of drugs in the nuclei of tumour cells and induce a high rate of apoptosis. Keywords: Carbon Dots (CDs), Fluorescence, Spectral Analysis, Cytotoxicity, Apoptosis
Publication date: 01/03/2022

https://ijbpas.com/pdf/2022/March/MS_IJBPAS_2022_5821.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.3.5821