ABSTRACT

Genetic variation is a term used to explain the DNA disparity between individuals or the variations between populations. Various genetic variations have been reported across the Saudi population. While the origin of these variations is attributed to genetic factors, environmental factors also play a significant role in the phenotypical expression of the symptoms in MetS. The genetic factors can be attributed to natural selection due to the transfer of initially beneficial traits from ancestral generations to the present-day generations. Consanguinity marriages and inbreeding play a critical role in the genetic inheritance of traits that increase the risk of MetS. High frequency alleles are found in the incidence of type 2 diabetes, dyslipidaemia, hypertension and obesity—all of which contribute largely to the incidence and prevalence of MetS. This syndrom is more prevalent among females than males due to increased levels of inactivity in the former population. Keywords: Genetic Variation, Metabolic Syndrome, Saudi Population, Type-2 diabetes
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_2047.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.2047