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EFFICIENT, MICROWAVE ASSISTED SYNTHESIS OF 4-(substituted fluoro-phenyl)-substituted-6H-1-thia-5, 7, 8, 9a -tetraaza-cyclopenta[e]azulenes And Their MICROBIAL ACTIVITY
Authors: Vikas R. Bhosale , VALMIK S. KAPASE, KULBHUSHAN A. SASANE, LIMBARAJ R. PATIL*

ABSTRACT
Organic compounds having heterocyclic ring and fluorine atom are most widely studied in the last decade. Present work focus on the synthesize of 4-(substituted fluoro-phenyl)-substituted6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulenes using microwave irradiation technique. Reported ten derivatives were efficiently synthesized using (2-Amino-5-substituted-thiophen-3- yl)-(fluoro-phenyl)-methanone and (1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid. This microwave assisted synthetic protocol is interestingly rapid with good percent yield. Synthesized compounds were screened for microbial activity and 50% of them found good active against tested microorganisms. Keywords: Microwave assisted, T3P, Hydrazine, Carboxylic acid hydrazide, DMF, Microbial activity
Publication date: 01/12/2021
    https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_2040.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.12.2040

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