ABSTRACT

The different etiological factors are involved in the pathobiology of neuropathy pain. Among the notable factors are diabetes, overconsumption of alcohol, deficiency of vitamins, and certain drug treatments like anticancer agents severely deteriorates the normal physiology of somatosensory nervous system. The genesis and time duration of painful neuropathy is complex phenomenon creating the hurdles in the treatment guidelines with the presently available drugs. Therefore, the management of neuropathy is becoming a challenging task for the researchers. Outcome of the pain research have revealed that differences in the functions, and mutations in genes responsible for genesis of neuropathic pain plays a vital role, and involved in the modulation of responses to the many analgesic drugs. In this context, the understanding the complete physiology of sodium channel is becoming quite obvious task for the successful management of neuropathic pain. The current review highlighted the involvement of different types of sodium channels, their correlation with development of neuropathy which will reveals the different possible opportunities in the direction of management of neuropathic pain. Key words: Sodium channels, neuropathic pain, tetrodotoxin (TTX)
Publication date: 25/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_JAN_SPCL_2_2064.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.2064