To achieve increased palatability in orally delivered products, numerous formulations with improved
performance and acceptability have been developed. Fast dissolving tablets are a new trend in unique
medication delivery systems that have seen an increase in demand over the last few decades.
Disintegration of tablets is an essential step in achieving rapid drug release. Fast dissolving, quick
melting, chewable and orally dissolving or disintegrating tablets are unit solid dosage form indefinite
quantity that disintegrate rapidly and dissolve within the mouth without need of water. This type of
feature in a dosage form is obtained through the addition of several excipients, the most important of
which is the disintegrant. The fundamental issue in developing fast dissolving tablet formulations is to
ensure that they disintegrate quickly, have a good tongue feel, and have a high breaking force for tablet
strength. The disintegration of dosage forms is influenced by a variety of physical factors of
superdisintegrants, including the percentage of disintegrants used in formulation, the proportion of
disintegrants used, compatibility with other excipients and the presence of surfactants, tablet hardness,
nature of drug substance mixing, and types of alternative excipient addition. Natural superdisintegrants
includes chitin and chitosan, Guar gum, Locust Bean Gum, Lepidium sativum, Plantago ovata, Mango
Peel Pectin, Dehydrated Banana Powder (DBP), Agar, Hibiscus Rosasinensis linn Mucilage, Gum karaya,
Fenugreek Seed Mucilage, Gellan gum (kicogel) etc. The focus of this review is on the various types of
natural superdisintegrants used in MDT, as well as their mechanisms and applications.
Keywords: Superdistintegrants, Tablets, Formulations, Excipients
Publication date: 25/01/2022
https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_JAN_SPCL_2_2058.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.1.2058
