ABSTRACT

The main objective of the current study was to make and test continuous Repaglinide (RPGN) matrix pills using aloe vera mucilage treated as a release modifier. A long-acting tablet should release the required amount of medication with pre-determined kinetics in order to maintain the effective plasma concentration that can be performed by making the drug release in a predetermined and repetitive manner. These matrix tablets are compressed using a direct compression method. The structure of the different tablets was prepared using a different material: polymer ratio i.e., 1: 1, 1: 2, 1: 3, 1: 4, and 1: 5. Dry powder mucilage extracted from Aloe vera leaves was tested with a resting angle, LBD, TBD, Carr index, and Hausner scale. Prepared pills were tested according to pharmacopoeial standards. It was observed in kinetic research that all formulations follow the kinetics of the first order and in particular the drug release in its dosage form. The current work clearly demonstrates the possible use of ground aloe vera (PAG) to correct drug release using different dosages. We can conclude that the modified matrix tablets that use PAG as mucilage can be used as a release mechanism in the formation of continuous matrix tablets. Keywords: Sustained release matrix tablets, natural polymers, repaglinide, synthetic polymers, PAG
Publication date: 25/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_JAN_SPCL_2_2057.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.2057