Introduction
Acute kidney injury presents as major complication of infective and non-infective aetiology.
Acute febrile illness is a major cause of mortality.Our study aims to study incidence and
spectrum of acute kidney injury in dengue.
Material and Methods
The cross sectional observational study was conducted in The Department of General
Medicine at Dr D.Y. Patil Medical College, Hospital & Research Centre, situated in Pimpri,
Pune. Approval was taken from Institutional Ethical Committee. All patients admitted to
medical wards and MICU in Dr D.Y Patil Hospital, during September 2018 – August 2020,
diagnosed with acute febrile illness were subjected to the study as per study design. A total of
100 patients of acute febrile illness admitted in all medical wards and MICU were selected
for the study. The diagnosis was made as per the standard diagnostic criteria. All patients
aged more than 12 yearsand all patients who present with symptoms of acute febrile illness
were included in our study. Patients with age less than 12 years, pregnant females, chronic
kidney disease patients, immunocompromised patients were excluded. Results
Mean age of the participants in our study was 36.8 ±15.1 years. Out of 100 patients, 86 (86.0)
participants were male and 14 (14.0) participants were female. According to RIFLE criteria,
it was observed that 60 (60.0) participants were in Normal Grade, 17 (17.0) participants were
in Risk Grade, 9 (9.0) participants were in Injury Grade and 14 (14.0) participants were in
Failure grade. According to AKIN grading, it was observed that 61 (61.0) participants were
in Normal Grade, 21 (21.0) participants were in Grade 1, 11 (11.0) participants were in Grade
2 and 7 (7.0) participants were in Grade 3. According to RIFLE criteria, It was observed that
among the 74 Dengue NS1 positive participants, 52 participants were in Normal Grade,10
participants were in Risk Grade, 5 participants were in Injury Grade and 7 participants were
in Failure grade and as per AKIN grading 52 participants were in Normal Grade, 12
participants were in Grade 1, 7 participants were in Grade 2 and 3 participants were in Grade
3.
Conclusion
Dengue is most common cause of AFI and AKI in this study. Acute Kidney Injury is major
risk factor for morbidity with patients requiring Renal Replacement therapy in few patients in
this study.
Keywords: Dengue, acute febrile illness, acute kidney injury, AKIN, RIFLE
Publication date: 15/02/2022
https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_FEB_SPCL_1045.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.2.1045
