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PROSPECTIVE CROSS-SECTIONAL STUDY TO EVALUATE AUTONOMIC DYSFUNCTION AND CSF ABNORMALITIES IN PATIENTS DIAGNOSED WITH ACUTE NON-TRAUMATIC QUADRIPARESIS/QUADRIPLEGIA IN A TERTIARY CARE HOSPITAL
Authors: Singh S , CHAUDHARY GA, MAHASHABDE ML AND VOORA NS

ABSTRACT
Aim: To evaluate autonomic dysfunction and CSF abnormalities in patients diagnosed with Acute Non-traumatic Quadriparesis/Quadriplegia Materials and Methods: Present study was a prospective cross- sectional type of study was conducted among 40 patients diagnosed with acute onset non traumatic quadriplegia / quadriparesis visited the department of Medicine of Dr. D. Y. Patil Medical College and Hospital Pimpri, Pune. Detailed medical history was taken for all selected patients. They were examined in detail with careful general, systemic and neurologic examination according proforma. Examination was done in a separate examination room to interpret the site of the neurological lesion through clinical signs and to reach a provisional diagnosis, before subjecting to further biochemical and radiological investigations according to the study design. Results: Mean age of patients in the study population was 43.92+14.36 years. Majority of them (32.5%) were in age group of 51 to 60 years. Of them 65% were males and 35% were females. Majority 60% had onset of quadriparesis more than 5 days, 27.5% had 1 to 5 days and 12.5% had onset <24 hours. Breathlessness was reported in 57.5 % of cases, fever in 52.5 percent, and petechiae/rash in 27.5 %. Majority 25% had GBS. Autonomic dysfunction was seen among 65% of cases. Among them 15% had bradycardia, 42.5% had tachycardia, 105 had orthostatic hypotension, 5% had diaphoresis, 5% had sialorrhea, 32.5% had bladder dysfunction. The most common abnormal CSF findings were cytoalbuminologic dissociation (30%), pleocytosis (12.5%), traumatic (7.5%), and oligoclonal bands (5%). Conclusion: Autonomic dysfunction was seen among 65% of cases. The most common abnormal CSF findings were cytoalbuminologic dissociation followed by pleocytosis, traumatic and oligoclonal bands. Keywords: Quadriparesis, Non-traumatic, Autonomic dysfunction, CSF
Publication date: 15/02/2022
    https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_FEB_SPCL_1044.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.2.1044

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