ABSTRACT

The Aim of this research work was to develop a bilayer tablet of Antihypertensive drug having sustained release layer (SR) and immediate release layer (IR) of Ramipril. The combination of these two layers in a single dosage form will reduce the frequency of drug administration and increase patient compliance. The floating matrix release layer was prepared by using swallable polymer HPMC K100, carbapol and immediate release layer was prepared by using superdisintegrant i.e. Sodium Starch Glycolate (SSG) by wet granulation. All physicochemical properties were evaluated for tablets. And all the values were found within limit. The optimized batches F6 and I3 by taking biphasic drug release pattern. In-vitro drug release study was carried out using USP Type-2 paddle apparatus, In-vitro drug dissolution study indicate that increasing concentration of polymers which decrease the rate of drug release. And result showed that carbapol 934P in floating matrix layer can control the drug release up to 8hrs. The mechanism and rate release of Ramipril from the prepared floating tablets were analyzed by fitting the dissolution data into the zero order, First order, Higuchi and Korsmeyer-Peppas equation. The Bilayer tablet of optimized batch fitted in to zero order release which show linear equation with (r2 value 1) and release pattern which indicate by diffusion. Keyword: Ramipril, Bilayer Tablet, Immediate Release, floating matrix delivery system
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5914.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.2.5914