ABSTRACT

Dementia is a syndrome of failing memory and other intellectual functions with little or no disturbance in consciousness. Degeneration of the cerebral neurons is one of the commonest and vital causes for dementia with increasing age, thereby leading to deterioration in the ‘quality of life’ in elderly. Traditionally rhizomes of Acorus tatarinowii Schott belonging to family Acraceae. The rhizomes of Acorus tatarinowii Schott has been historically used to treat neurodegenerative diseases in china for thousands of years. But its effect on learning and memory is not scientifically proven. The present study was carried out to study the effect of ethanolic extract of Acorus tatarinowii Schott on memory deficits caused by Scopolamine in rats. In wistar rats of either sex, amnesia was induced by subjecting Scopolamine (0.3mg/kg i.p) for seven days. Ehanolic extract of Acorus tatarinowii Schott (500mg/kg, p.o) was evaluated for its nootropic activity in terms of Transfer Latency (TL) by using elevated plus maze and step down passive avoidance test. Rats were sacrificed at the end of study and Acetyl Cholinesterase (AChE) enzyme activity was estimated. The extract showed significant improvement in ‘learning’ and ‘memory’ as compared to control group in all the models and also showed significant reduction in acetylcholine-esterase activity. Keywords: Amnesia, Transfer Latency, Acorus tatarinowii Schott, Acetylcholine esterase, scopolamine, nootropic
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5912.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.2.5912