ABSTRACT

Objective: Mercury is a multidisciplinary global pollutant of environment, mainly accumulating in the liver and kidney inducing hepatorenal toxicity, oxidative stresses, and tissue damages. The current experimental study is developed to scrutinize the protective potential of betulinic acid and rotundic acid against mercuric chloride induced hepatorenal toxicity. Methods: HgCl2 was dosed orally about 1.29 mg/kg of body weight upto 7 days and betulinic acid and rotundic acid (5mg/kg per body weight) was nursed for another 7 days on intoxicated rats. Results: In the present investigation, there is a tremendous alterations in the volume of Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Lactate dehyrogenase, albumin, bilirubin, total cholesterol, creatinine and urea amounts were noticed in the mercury intoxicated rats blood serum. Thus, the pursuit of liver marker enzymes namely ALP, AST, ALT and LDH were increased significantly additionally albumin content of rats intoxicated with mercuric chloride was decreased simultaneously. The therapy of Betulinic acid and Rotundic acid on the intoxicated rats shown the normal level of liver marker enzymes as well as maintained their levels near to the normal conditions. Conclusion: The present experimental work indicates the detoxify effects and defensive effect of betulinic acid and rotundic acid against HgCl2 induced hepatorenal toxicity. Keywords: Liver marker enzymes, Total cholesterol, Urea, Creatinine, Mercuric chloride, Betulinic acid, Rotundic acid
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5911.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.2.5911