ABSTRACT

Rhazya stricta is an inhabitant plant found in the deserts of Pakistan. The vegetations of this plant hold alkaloids, glycosides, triterpenes and tannins and it has a plentiful quantity of natural alkaloids. Natural alkaloids have many organic actions like as antihypertensive, antibiotic and anticarcinomious actions and also revealed as CNS activators. Phytochemical examination has acknowledged more than hundred alkaloids. For assessing Antibacterial and Analgesic effects of Rhazya stricta, the plants were collected in their respect season and dried under shade for 15 days and then the plants were converted in fine powder. A dark-brown semisolid was obtained by soaking the powder in ethanol for 7 days and subsequent evaporation of solvent. The analgesic activity was determined by induced writhing test by administration of 6% acetic acid solution. However minimal significant activity was observed. Antibacterial activity was determined by Disc Diffusion Method and Well Diffusion Method. Significance antibacterial activity was observed by using Disc Diffusion method cultures of E.coli bacteria. However, appearance of zone in the cultures of C.perfringes (an aerobic bacteria) when tested for antibacterial activity by Well Difusion method declares that R.strichta possesses such activity. Moreover, activity gains E.coli showed positive result when tested by Well Diffusion method. From the stated tables and by the experiments performed this could be concluded that R. stricta has positive activity against C.perferingens and E.coli. However it showed minimal analgesic activity against the pain induced in Albino mice. Keywords: Rhaya stricta, Antibacterial, Analgesic, Disc Diffusion method, Well Diffusion Method
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5873.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.2.5873