ABSTRACT

The aim of this study was to formulate and evaluate herbal mouth ulcers gel using Psidium guajava L (Guava) leaves powder at different concentrations. Carbopol 934, Propylene glycol used as a gel base to form create herbal gel. Formulations were stored at 8, 25 and 40°C for four weeks to investigate their stability. Color, centrifugation, liquefaction, phase separation, pH. Powdered Guava leaves had no contact with Polymer, according to infrared spectroscopy. The gel was clear and homogeneous, with a pH range of 6 to 7. Viscosity, Spreadability and Extrudability properties are within the range which demonstrates the rheological behavior of the formulations. Antimicrobial trials of formulations revealed high effectiveness against Candida albicans and Aspergillus niger. Powdered guava leaves have a major antioxidant effect, according to experimental evidence from in vitro studies. The developed herbal formulation was stable, safe, and effective when compared to synthetic formulations was confirmed after the stability studies. Keywords: Guava leaves powder, Aqeous Gel, Mouth ulcers, Carbopol934, Candida albicans
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5859.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.2.5859