ABSTRACT

Background: Diabetes mellitus is characterized by a syndrome of chronic metabolic disorder with hyperglycemia as a common denominator. One of the less frequently used glycemic markers in the diagnosis of diabetes is serum fructosamine. Fructosamine is formed when glucose reacts with the amino groups of plasma proteins in an irreversible reaction. Its concentration is primarily determined by blood glucose concentration and plasma protein lifespan. Main body: Glycosylated Hemoglobin (HbA1c) have been used for decades for diagnosis of diabetes. However, it is altered in many situations including red blood cell wall defects, hemoglobinopathies, chronic renal failure, and chronic liver disease, and various other situations. Therefore, the utility of short-term glycemic markers like Serum Fructosamine is gaining popularity. Glycated serum proteins, of which albumin is the most abundant, are referred to as fructosamine. Fructosamine is made in the same way as HbA1c is made, by nonenzymatic glycation of protein amino groups. Since albumin has a much shorter half-life of about 20 days than HbA1c, it reflects more short-term (2–3 weeks) shifts in glucose regulation than HbA1c. Fructosamine measures total serum protein-bound to glucose and represents blood sugar levels for a period of two to three weeks, therefore, it could be very useful for tracking early treatment response. Conclusion: The measurement of Fructosamine is simple and precise in terms of technology. It may be used where more frequent and tight glycemic control is targeted and in situations where HbA1c as a glycemic marker is inappropriate. Its measurement is very effective in gestational diabetes where there is a need to monitor blood sugar levels more frequently and more closely. Because of its application to diabetes and ageing pathologies, fructosamine has seen a surge in biomedical research. Keywords: Diabetes; Glycemic markers; Serum Fructosamine; Glycosylated Hemoglobin (HbA1c); Gestational diabetes
Publication date: 01/02/2022

https://ijbpas.com/pdf/2022/February/MS_IJBPAS_2022_5739.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.2.5739