ABSTRACT

ntranasal drug delivery is an optimistic and convenient way for delivery of drugs which are ineffective orally due to extensive hepatic metabolism. The CNS acting drugs which are required to be present in optimum concentration in brain can be best possibly administered by nasal route. The objective of this study was to prepare nasal in-situ gel of an anti-Alzheimer drug Memantine HCl for nasal administration. The nasal in-situ gel was formulated using ion induced gelling polymer like gellan gum. Mucoadhesive property of gel increases the nasal residence time of drug, which results in enhanced absorption. FTIR and DSC studies were carried out to check the compatibility between drug and excipients used in formulation. The formulations were evaluated for various parameters such as gelation, viscosity, drug content, drug release properties along with good mucoadhesive strength. Keywords: Nasal in-situ gel, ion induce gel, Memantine HCl, gellan gum
Publication date: 25/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_JAN_SPCL_2_2027.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.2027