ABSTRACT

Self-Nano Emulsifying Formulations for Oral Drug Delivery Systems (SNEDDS)are the most prevailing and commercially available oil-based approach for drugs that exhibit low dissolution rate and inadequate absorption. SNEDDS for oral drug delivery are highly in quest due to their innumerable benefits like better portability, improved stability, and higher drug loading, coupled with ease and economy of their production. SNEDDS is a proven method for increasing the solubility and bioavailability of lipophilic compounds. Encapsulating a drug in SNEDDS can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption resulting in enhanced bioavailability. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed for increasing efficacy and patient compliance. This paper presents an overview of the SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds, their mechanism, formulation excipients and potentials of SNEDDSs, recent advancements, advantages and disadvantages of SNEDDSs formulations. Keywords: Self-Nano Emulsifying Drug Delivery Systems (SNEDDSs), Oral Delivery, Poorly water soluble drugs, Solubilization, Advancements in SNEDDSs
Publication date: 25/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_JAN_SPCL_2_2012.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.2012