ABSTRACT

Diet and nutrition are known to contribute to different rates of cancer prevention/progression. Estrogens are sex hormones which exert many biological and physiological functions in humans. Deficiency of estrogens postmenopause, result in multifaceted complications in women including increased risk for the development of cardiovascular diseases and osteoporosis. The gold standard treatment for osteoporosis in postmenopausal women is Hormone replacement therapy with synthetic estrogens. The major limitations of estrogen therapy is the potential proproliferative effects of estrogen on reproductive organs like breast and uterus that predisposes the recipient to high risk of developing breast and endometrial cancers. But these side effects could be avoided with the use of phytoestrogens, as many of them are selective estrogen receptor modulators exhibiting tissue selectivity. Biochanin A, Formononetin and Resveratrol are phytoestrogens which mimic the actions of endogenous estrogens but are devoid of the side effects of synthetic estrogen. Although a plethora of scientific reports are available to support the osteoprotective effects of these phytoestrogens, scientific reports pertaining to their anti-tumour property is scanty. Therefore it is desirable to study the antitumour properties of these phytoestrogens on suitable in vitro or in vivo model systems. This would justify and provide a scientific rationale for its probable use as a safe potential alternative to Hormone Replacement Therapy with estrogen. This would also help to understand the anticarcinogenic/procarcinogenic effects of these compounds thereby throwing light on their mechanisms of action. This preliminary study is an attempt tounderstand the in vitro antitumour properties of three important dietary phytoestrogens Biochanin A, Formononetin and Resveratrol. Keywords: Formononetin, Biochanin A, Resveratrol, Phytoestrogens, Agrobacterium tumefaciens. Phytopathogenicity tests
Publication date: 01/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_6387.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.6387