ABSTRACT

To develop an ibuprofen Transemulgel gel with a capability for both topical and systemic drug delivery. Aloe vera is most popular in treatment of dermatologist disorder in acne of burn, tan and wound healing. The study was designed for crude Aloe vera extract, development of oil in water (o/w) emulsion, preparation of gel base using Aloe vera extract and formulation of the emulgel for topical application.The formulation was prepared by using Ibuprofen (NSAID) and propylene glycol as permeation enhancer.The pH and viscosity of the aloe vera emulgel were noticed to be 7.2 and 750 centipose (cps) respectively. The interaction study between photochemical and the excipients was carried out using Fourier transform infrared (FTIR) Spectroscopy. UV spectrometric analysis of plant extract was carried out respectively. Keywords: Transemulgel, Aloevera gel, Ibuprofen, Fourier transform infrared (FTIR) spectroscopy
Publication date: 01/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_5827.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.5827