ABSTRACT

Mouth dissolving films are solid dosage form that disintegrates or dissolves within a minute when placed in the mouth facilitating the rapid absorption thereby reducing the first pass metabolism. The aim of this study is to formulate and evaluate the fast dissolving oral film of Memantine hydrochloride which is used in the treatment of Alzheimer’s disease. The films were prepared by using hydroxyl propyl methyl cellulose E5 as a film based synthetic polymers by solvent casting method. The formulated Memantine hydrochloride fast dissolving oral films were found to be acceptable when evaluated for weight uniformity, thickness, drug content, in-vitro drug release, folding endurance and disintegration time. The film was disintegrated within thirty seconds to release drug rapidly. Keywords: Memantine hydrochloride, mouth dissolving film, solvent casting method and hydroxyl propyl methyl cellulose
Publication date: 01/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_5820.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.1.5820