ABSTRACT

Vaginal dose formulation is known for several drugs. The vaginal delivery system has many benefits, including a wide surface area and sufficient blood supply due to the lack of the firstpass metabolism. Novel methods of drug delivery have developed to lower the risk of vaginal infection. One such way is the 'Bioadhesive Vaginal Drug Delivery System' Film combines the advantage of gels and other pharmaceutical dosage forms. A vaginal film formulated with a plasticizer such as Glycerine, HPMC K4M, SCMC and, chitosan improves flexibility and overcomes mechanical tension. The Films prepared by Solvent Casting Method, unless it passes evaluation tests such as FTIR, DSC, Folding Endurance, in-vitro release in SVF (Stimulated Vaginal Fluid), in-vivo drug release profile. In comparison to other formulations, Vaginal Film is becoming more suitable and convenient. Self-insertion is possible because films are unlikely to be associated with leakage and messiness. Keywords: Bioadhesive, Vaginal Film, Solvent Casting Method, Vaginal Infection, and Stimulated Vaginal Fluid
Publication date: 01/01/2022

https://ijbpas.com/pdf/2022/January/MS_IJBPAS_2022_5817.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.1.5817