ABSTRACT

The present investigation was aimed to formulate and evaluate Matrix- type Transdermal delivery system containing an antihistaminic drug, Bilastine with different polymer concentration by the solvent casting technique & explore the effect of polymers on the in-vitro drug release of Bilastine across skin Matrix. The present investigation aims to formulate and evaluate of medicated skin patches for the treatment of Urticaria. Skin patches were prepared by using hydroxyl propyl methyl cellulose HPMC K100 and Eudragit RS 100 as polymers, ethyl cellulose as plasticizer, PEG-4000 as permeation enhancers and chloroform as solvent. Prepared patches were subjected to different evaluation studies in which permeation studies were performed by using Franz diffusion cell apparatus, folding endurance, thickness, weight variation, percentage moisture uptake, etc. The results showed that F5 batch found were optimized i.e. thickness 0.11mm, weight variation about 2%, folding endurance about 103 folds, moisture uptake 1.03%, and showing drug assay about 97.57% with drug release in first hour 9.12 and cumulative drug release of 75.71%. The stability study proved that optimized batch was stable at accelerated stability conditions. Keywords: Transdermal, Urticaria, Permeation enhancer, In-vitro permeation study
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_2025.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.2025