ABSTRACT

The aim of the present investigation is to develop and evaluate Terbinafine hydrochloride microemulgel. Terbinafine hydrochloride is FDA approved antifungal drug for treatment of topical fungal infection. It is a BCS class II drug; has poor bioavailability. Now, microemulgel has developed as one of the most interesting topical preparation in the field of pharmaceutical sciences. Microemulgel as a delivery system is advantageous to use such as ease of administration, increased residence time at applied site, steady drug release with improved bioavailability, better thermodynamic stability and high transdermal permeability over simple conventional formulations. The microemulgel of Terbinafine hydrochloride were prepared, using carbopol 940 and HPMC as a gelling agent, oleic acid as oil, parabens as preservative, tween 20 as emulgent and penetration enhancer. The prepared microemulgel formulation was inspected visually for appearance, spreadability, homogeneity, viscosity, pH, % drug content and In vitro diffusion studies. Results obtained has proved that development of terbinafine hydrochloride containing microemulgel will be more effective however its clinical efficacy must be understood using clinical trials. Keywords: Microemulgel, Terbinafine hydrochloride, Carbopol 934, HPMC, penetration enhancer
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_2019.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.2019