ABSTRACT

To improve the patient compliance for bitter drugs, Taste masking technique becomes requisite especially in the pediatric, geriatric and non-cooperative patient. Pharmaceutical formulations like Fast dissolving, oro-dispersible, mouth dissolving, and other formulations which come in contact with taste buds, taste is one of crucial factor to be considered. It is important to mask the bitter taste of drugs for the improvement of patient compliance. This study aimed to mask Temlisartan taste by an efficient process of cyclodextrin inclusion complexation. Taste improvement of drug by ?Cyclodextrin was done by simple complexation approach using solvent evaporation method. The present study characterized the possibility of inclusion Complexation of Temisartan with ?Cyclodextrin as an approach for taste masking. Improved capability of ?-cyclodextrin in taste masking for Temisartan was evaluated by formulating a complex. The objective of this study was to mask the bitter taste of the Telmisartan and the drug polymer complex (DPC) were prepared in different ratio (1:1, 1:2 1:3 1:4, 1:5 & 1:6) by solvent evaporation method. The evaluation of DPCs were carried out by determining Drug content, In-vitro evaluation of drug complex & Threshold value determination. 200µg/ml is the optimized threshold value for the DPC and 1:3 ratio was selected which masked the taste of drug. Keywords: Bitter taste, Threshold value, drug polymer complex, Taste bud, Cyclodextrin
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_2010.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.2010