ABSTRACT

The aim of present study is to evaluate the utility of ultraviolet spectroscopic method for determination of synthesis of ?-cyclodextrin based nanosponge. These nanosponges were prepared by melt method, solvent assisted synthesis, ultrasound assisted synthesis and microwave assisted synthesis using ?-Cyclodextrin as a polymer and DPC as a cross-linker. FTIR spectra of all the synthesized nanosponges were recorded and the characteristic carbonate peak was obtained at 1740 cm-1. Further spectral analysis was performed using ultraviolet radiations as per the objective. Therefore, ultraviolet spectral copies of all the starting materials, intermediate and end products; nanosponges were recorded and compared in the wavelength region of 190 to 380 nm. ?-Cyclodextrin didn’t show any peak while DPC showed two peaks at 256 and 217 nm corresponding to phenyl rings and carbonyl groups. However, the hypsochromic shift in ?maxvalue of carbonyl group in synthesized ?-CD based nanosponges was observed and prominent peak appeared at 205 + 2 nm. This shift can be attributed to the presence of ?-Cyclodextrin molecules on either side of carbonyl group in nanosponge rather than phenoxy group present in DPC. Hence, the study could point that ultraviolet spectroscopy can be used as a preliminary tool for confirming the synthesis of ?-CD based nanosponges. Keywords: ?-Cyclodextrin, nanosponge, ultraviolet spectroscopy, analytical method
Publication date: 15/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_1041.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.1041