ABSTRACT

Vildagliptin is an Oral Anti- Hyperglycaemic agent (antidiabetic drug) belonging to a new group of drugs called as dipeptidyl peptidase -4 inhibitor (DPP-4 inhibitor). Vildagliptin has been shown to reduce hyperglycaemia in type 2 Diabetes Mellitus. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the Islets of Langerhans in the pancreas & reduces the blood sugar level. The present review assesses the various approaches for analysis of Vildagliptin in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, UHPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of Vildagliptin in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on Vildagliptin. Keywords : Vildagliptin; Analytical Profile; HPLC; HPTLC; UPLC; Bio-analytical; Stability indicating
Publication date: 15/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_1030.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.1030