ABSTRACT

The main aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Ketoconazole. To formulate Ketoconazole emulgel, two gelling agents were used: Carbopol-934 and Carbopol-940. The emulgel which were prepared are evaluated for their physical appearance, pH measurement, spreadability, viscosity, drug release, antifungal test, skin irritation test, and stability. Comparison was done by using commercially available Ketoconazole cream. The prepared formulation of emulgel showed acceptable physical properties including color, homogeneity, consistency, pH value and spreadability. It was found that the antifungal property and drug release for optimized formulation is higher than the marketed Ketoconazole cream. The highest activity was observed with F2 formulation, where percentage inhibition found to be 71.53% than the marketed product, which was found 45.43%. The cumulative amount of drug release range varied between 76.69% to 66.13%. at 24 hrs. As all the evaluation parameters were performed, so there was no skin irritation seen. It was also observed that, after storage of formulation for 3 months, stability study showed that the physical appearance, rheological study, in vitro drug release, and antifungal activity of emulgel remains unchanged. In general conclusion,it was suggested that the prepared formulation (emulgel) of drug release for sustained drug delivery in a controlled manner is succeed in comparison with cream. Keywords: Emulgel, Ketoconazole, Topical drug delivery, antifungal activity
Publication date: 15/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_DEC_SPCL_1013.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.1013