ABSTRACT

Drugs administered through the oral route greatly deteriorate in the Gastrointestinal Tract (GIT) or Liver; for those drugs, nasal administration is a substitute route. The Nose to Brain delivery approach can replace invasive drug transportation methods to the brain with enhanced drug absorption and low systemic adverse effects. To improve nasal absorption, several strategies are available; one such is lipid nanocarriers (e.g., NLCs). Nanostructured lipid carriers (NLCs) are regarded as a good drug transport approach without any drug molecule alternatives. NLCs are composed of lipids, surfactants, and solvents. This review showcases the different types of NLCs, composition and mechanism, the rationale for developing nose-to-brain targeting, NLCs preparation methods and evaluation, guidelines for the design of lipid-based formulations, marketed products, future scopes, and toxicity studies of nose-to-brain drug delivery systems were also focused in this review. Keywords: Non-invasive, lipids, nanostructured lipid carriers, nose to brain delivery, toxicity
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_10201.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1020