ABSTRACT

Back ground and objectives: Alphonsea sclerocarpa a well-known traditional herb famous for its immense use in folklore medicine. Since diabetes is the most ubiquitous health issue in the century, the drive towards antidiabetic drug discovery is continued for decades. In this regard, the current work is engrossed in determining the antihyperglycemic potential of A. sclerocarpa leaves. Methods: Antihyperglycemic through the Streptozotocin-induced diabetic rat model was performed and Glibenclamide was taken as standard, the flavonoid-rich fraction of A. sclerocarpa was given to the animals in two doses (200 and 400 mg/kg body weight), and blood glucose and lipid levels were analyzed along with histological studies. Phytochemical screening, total phenolic, flavonoid, and tannin contents were determined to support this investigation. The antioxidant activity studies by DPPH assay, NO free radical scavenging assay, and total antioxidant assay were also screened using standard protocols. Results: Preliminary phytochemical screening of the leaf extract exposed various secondary metabolites. The results show that the plant is rich in polyphenolic contents and regularized blood glucose levels at 200 mg/kg and 400mg/kg dose in 15 days. The biochemical studies disclosed that the plant significantly improved the abnormal blood glucose and lipid profile. The histopathological study sustenance the protective effect of the plant against diabetes. Conclusion: To conclude, all the biochemical data professed that the flavonoid-rich fraction of A. sclerocarpa is effective among all the extracts to give protection against oxidative stress and subsequent improvement of the blood sugar levels, serum lipid parameters, and ?-cell recovery. The antioxidants of the phytochemicals embedded in the extract may be responsible for the stated activity. Key words: Alphonsea sclerocarpa; antioxidant; anti-hyperglycemic; acute toxicity; lipid profile
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1053.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1053