ABSTRACT

Objective: Current research is to investigated the anti-inflammatory activity of two Indian medicinal plants, Indigofera cordifolia and Indigofera glandulosa. Methods: Leaves of the both plants were collected and extracted with ethanol. Both ethanolic extracts were subjected to invitro anti-inflammatory activity evaluation by HRBC assay and COX enzyme Inhibition assay. COX-1 inhibition assay employed indomethacin as reference standard, while COX-2 inhibition assay employed celecoxib as reference. Results: Indigofera cordifolia displayed highest percentage protection of 80.9±3.3 in HRBC assay, and percentage inhibition of 72.9±3.4 against COX-1, and 80.3±1.4 against COX-2. Indigofera glandulosa displayed relatively low percentage inhibition of 69.4±1.4 against COX1 and 75.8±2.7 against COX-2. Conclusion: Both plants under investigation displayed good anti-inflammatory activity. Comparatively Indigofera cordifolia disclosed more anti-inflammatory activity and specificity towards COX-2 enzyme than Indigofera glandulosa. Keywords: Indigofera cordifolia, Indigofera glandulosa, Extraction, Anti-inflammatory activity
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1052.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.9.1052