ABSTRACT

Cancer continues to be the most unconquerable and grievous medical condition in developing countries. In the present study, a series of coumarin-triazole hybrid compounds were designed and synthesized for anticancer activity. For all compounds, MTT assay was done by using four different cell lines like Hela (Cervical cancer cell line), MCF-7 (Breast cancer cell line), A-549 (Lung cancer cell line), and IMR-32 (Neuroblastoma cell line). Most of the compounds showed moderate to good efficacy against different cancer cell lines. Among all, the compound 7h exhibited the best anticancer activity against the MCF-7 cell line. Keywords: Cancer, Triazole, Coumarin, Cell line, MTT assay
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1051.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1051