ABSTRACT

Plant based drugs are useful to treat different ailments with less side effects compare to synthetic drugs. Anticancer agents which are available in the market are having various side effects apart from their therapeutic effectiveness. For this, we have estimated the anticancer activity of Taxillus tomentosus against EAC (Ehrlich ascites carcinoma) induced cancer in Swiss albino mice. We have prepared the ethanolic leaf extract of Taxillus tomentosus (TTEE) and their ethyl acetate fraction (TTEAF) and n-hexane fraction (TTNHF). These extract and fractions were tested at 50 and 100 mg/kg body weight doses against EAC induced mice using paclitaxel (PCTXL) at 5 mg/kg dose as standard, assessed the various antitumor and hematological parameters and compared to EAC control. The test extract and fractions resulted in decreased bodyweight of animals, especially at higher dose. The test substances also exposed lowered tumor volume, viable tumour cell count and packed cell volume compared to EAC control mice. The treatments of test TTEE, TTEAF and TTNHF have enhanced the mean survival time and percentage increased life span compared to EAC control, indicating anticancer activity. Also, the test substances returned the all-hematological parameters such as hemoglobin content, red and white blood cells, and differential leucocyte count. Hence, the test extract and fractions have shown anticancer activity against EAC induced mice which was comparable to standard drug PCTXL and TTNHF was the most promising fraction representing anticancer activity. Future research on isolation and purification of Taxillus tomentosus might be useful to obtain most promising agents to treat cancer.
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1047.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1047