ABSTRACT

Objective: The objective of present research is to identify the adverse drug reactions (ADR), study the pattern of ADRs caused by newly prescribed drugs and asses its prevalence in patients with chronic diseases. Methods: The study carried out in 500 bedded multispecialty Hospital at general medicine department over a period of three years. The data was collected from patient case sheet, treatment charts, and lab reports and by direct interviewing patients and their care takers.The collected data is analysed for determining causative drug's relationship to ADR, for assess causality of ADR, for ADR severity assessment and for determining preventability of an ADR. Predictability and preventability were also assessed. Data analysed using SAS version 9.1. Chi-square and p values were calculated using Medcalc’s calculator. Results: Among 330 cases, 409 adverse drug reactions were identified, which shows the probability of multiple adverse drug reactions in a single patient.Among various age groups adults (64.24%) show higher prevalence, with male at higher risk than female.Majority of ADRs were identified by doctors or prescribers 208(50.85%).Among 592 patients specific and symptomatic treatment was given for majority of 191 (46.69%) patients. The casuality assessment indicate that Possible and Probable are statistically significant.Most of ADRs were gastrointestinal 106 (25.91%) reactions, central nervous 72 (17.60%) reactions followed by cardiovascular 43(10.51%) reactions. A definite improvement was predominant in dechalleged patients whereas recurrence of symptoms was significantly observed among rechallenged patients with the respective suspected drug.In 409 ADRs cases majority (47.67%) weredefinitely preventable adverse drug reactions are followed by probably preventable adverse drug reaction. Conclusion: Adverse drug reactions are more common and preventable. Vigilance by physicians, clinical pharmacists and other healthcare professionals in detecting, diagnosing and reporting can reduce their impact. Keywords: WHO ART, Chi-Square Value / P-Value, Adverse Drug Reactions, Newly Prescribed Drugs, Chronic Diseases
Publication date: 25/09/2021

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https://doi.org/10.31032/IJBPAS/2021/10.9.1045