ABSTRACT

Etoricoxib is a highly selective COX-II inhibitor, used to treat pains of different etiologies. Etoricoxib has low aqueous solubility (201µg/ml) and high permeability and therefore classified as BCS class II drug. By formulating these drugs with cyclodextrins as inclusion complexes have shown to increase the bioavailability. Cyclodextrins when used as Complexing agents, enhance the solubility of poor water soluble lipophilic drugs. The objective of the present work is to formulate Etoricoxib cyclodextrin complexes by using ternary systems as Citric acid, Tartaric acid and PVP K-30 in order to enhance solubility and evaluate the enhanced solubility by in-vitro dissolution. The formulated complexes were evaluated for drug release by in-vitro dissolution. The prepared complexes were confirmed and characterized by FT-IR, DSC, SEM and XRD. Complexation with cyclodextrins is an effective method in order to improve the aqueous solubility of Etoricoxib. The release of Etoricoxib from complexes prepared with Hydroxy propyl ? cyclodextrin and citric acid (1:1:2M) by lyophilization method shows a drug release 100.85%, significantly higher than other cyclodextrin ternary complexes. Keywords: Etoricoxib, cyclodextrins, Kneading method, Solvent evaporationmethod
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1042.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1042