ABSTRACT

Dendrimers also called arborols or cascade molecules are highly ordered, branched structures, known to possess well-defined shape, size, homogeneity, symmetry, and an extensive number of end groups and functional groups. These end groups can help in conjugating drug moieties and navigate them through the bio membranes and contribute to appreciate targeted drug delivery than existing systems in most of the cases. Dendrimer molecules or hyperbranched polymers are characterized by a core, branches-conclusive of the generation of moiety and end functional groups. This review was aimed at discussing unique properties of dendrimers possessed due to their architecture and structure, types of dendrimers, and their applications in few areas of drug delivery. Donald A Tomalia and few other prominent researchers have great contributions to this field of cascade molecules. Starting from poly (amidoamine) (PAMAM), Poly (propylene Imine) PPI, frechet type dendrimers to micellar dendrimers, various variations of these molecules have helped the science of drug delivery as in enhancing solubility, bioavailability, achieving controlled release and sustained release, achieving the targeted release of the drug, being biocompatible, along with many unsaid effects. This review encompasses various drugs, their treatment with dendrimers, and the consequential effects produced. Keywords: Polydisperse dendrimers, Hyperbranched polymers, Arborols, Cascade molecules
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1039.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1039