ABSTRACT

Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. Nano/crystals owing to its ability to modify the physicochemical and biological properties of the drug have gained widespread attention among the research scientists. This review provides comprehensive detail on the associated advantages, challenges, factors affecting physicochemical properties, and optimization parameters about the stability of nanocrystals. In this review, the evolution of nanocrystals is discussed as first-generation simple nanocrystals, second generation nanocrystals within a carrier, and third-generation surface-modified nanocrystals. It also provides a detailed account of various preparation methods and evaluation of surface-modified nanocrystals. Keywords: Nanocrystals, Nanocarriers, drug delivery, solid lipid nanoparticles
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1038.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1038