ABSTRACT

Neurodegenerative disorder can be described as an irreversible gradual loss of neuronal cell which is essential to perform the normal brain functions and the continuous loss of neuronal cell ultimately leads to brain death. Alzheimer’s disease is defined as an irreversible neurological disorder which impairs the cognitive and intellectual function of human brain. The fresh leaves of Dalbergia diphaca (DD) was collected from the local flora in Vellore district, Tamil Nadu India for the Neuroprotective activity of Indian medicinal plants in Alzheimer’s disease. The doses (200 mg/kg and 400 mg/kg) of ethanolic extracts of ZL was used for the Neuroprotective activity of Indian medicinal plants in Alzheimer’s disease. The tested doses at 200 mg/kg and 400 mg/kg of ethanolic extracts of ZL showed significant neuroprotective behavioral study. These extracts bring back the declined level of brain neurotransmitters like dopamine, glutamate and antioxidant enzymes like catalase, glutathione peroxidase and glutathione reductase. In vitro neuroprotective activity for ethanolic leaves extracts of Dalbergia diphaca (DD) was performed on SH-SY5Y cells. The copper oxide nanoparticles synthesized from the ethanolic leaves extracts of ZL showed very good neuroprotective activity. Keywords: Neuroprotective, Alzheimer’s disease, Dalbergia diphaca
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1036.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1036