ABSTRACT

The condensation reaction of 1,3-cyclohexanedione, salicylaldehyde, and urea in the presence of ethanol as a solvent system yielded a novel mannich base, 1-((2,6-dioxocyclohexyl)(2- hydroxyphenyl)methyl)urea (1). UV-visible, FT-IR, 1H & 13C NMR, and elemental studies were used to determine the structure of ligand (1). IR and UV-visible spectra, molar conductivity, and EPR measurement were used to describe the structures of metal complexes (1a-1e) of the ligand (1). The geometries of all the complexes were octahedral. The antibacterial effect of ligand (1) and metal complexes (1a-1e) against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Klebsiella pneumaniae was investigated using the disc diffusion method. The metal complexes (1a-1e) were more significant than Ciprofloxacin, which served as a control. Keywords: Antibacterial activity, Mannich base, Staphylococcus aureus, Transition metal complexes
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_NOV_SPCL1112.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.1112